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王小莺

2020-05-221030人浏览

副教授、硕士生导师、博士

基本情况

王小莺，女，博士，副教授。就读研究生以来一直从事生物医用高分子材料的合成与改性研究，在合成新型生物医用材料、材料的结构与性能研究、组织工程支架的设计与构建以及支架材料的微观结构对细胞增殖、分化的影响等方面做了大量的研究工作，积累了丰富的科研经验。到目前为止，已主持了国家青年基金，教育部归国留学人员基金，广东省自然科学基金项目面上项目，广东省科技计划项目，广州市一般科学项目等多项项目的研究，并参与了多项国家基金面上项目，教育部博士点基金，广东省高等学校高层次人才项目的研究。已在SCI国际期刊发表研究论文40余篇，获得国际授权专利1项，中国授权专利7项。

 

联系方式

暨南大学生物医学工程系

暨南大学第二理工大楼230室，广州，邮编510632

Tel：+86-020-85226923

E-mail：wangxi@jnu.edu.cn

 

教育经历

1994.07-1998.06 湖北大学化学与材料科学学院高分子材料系，获工学学士学位。

2000.09-2005.06 中山大学高分子研究所高分子化学与物理专业，获理学博士学位

 

工作经历

2005.11-2007.12 德国马尔堡大学（Philipps University of Marburg）药学系，博士后。

课题：支化型聚酯纳米微球作为肺部药物控制释放载体的设计合成与性能研究

2008.02-2010.03 美国特拉华大学（University of Delaware）材料系，博士后。

课题：响应性的功能聚酯纳米微球作为肿瘤靶向纳米载体的研究

机械响应性水凝胶的设计合成及其在喉管再生组织工程支架材料中的应用

2015.9-2016．9 美国塔夫茨大学(Tufts University)生物医学工程系，访问学者。

2010.07-至今 暨南大学生物医学工程系副教授。

 

科研方向

生物医用高分子的设计合成及其医学上的应用研究

——生物活性化弹性共聚酯的设计合成及其生物活性化修饰

——具有形状记忆效应的弹性共聚酯在医用材料中的应用研究

——生物活性化可注射温敏水凝胶的构建及其在组织修复中的应用研究

——机械响应性及导电形状记忆高分子在医用高分子材料中的应用研究

 

 

已经获得的研究基金：

  1. 广州市科技计划, 201904010383, 新型铁基导电可降解弹性支架的构建及用于心肌再生的研究, 2019/04-2022/03, 20万.（主持）

  2. 广东省科技计划, 2014A010105027, 具有形状记忆效应的可降解弹性共聚酯的中试及用于组织工程小口径血管临床前研究, 2015\05-2018\05, 30万. （主持）

  3. 国家青年自然科学基金(21311028), 生物活性化弹性聚酯的合成及其在小口径人工血管中的应用，2012\1-2014\12, 24万. （主持）

  4. 忠信助研基金(50501671)，设计合成功能化的弹性聚己内酯及其在血管支架材料中的应用研究，2011\3-2014\3, 3万. （主持）

  5. 暨南大学引进人才科研启动基金(50624053), 设计合成生物活性化弹性聚酯及其在软组织工程中应用研究，2011\1\2013\12, 3万. （主持）

  6. 广东省聚合物材料重点实验室开放基金，生物活性化弹性聚酯的合成及其表征，2011\6 -2012\12，1.5万. （主持）

  7. 广东省高等学校高层次人才项目，环境双响应靶向控释载体联合传输化聊化疗药和纳米金治疗肿瘤，2012\01-2014\12. （参入）

  8. 国家自然科学基金面上项目, 31771047, 双重3D打印超弹性组织工程血管化骨及其促骨促血管形成协同作用与机制研究, 2018/01-2021/12, 60万元, 在研, 参与

  9. 国家自然科学基金面上项目, 31570964, 支架中昆布多糖对巨噬细胞的免疫调控活性及其用于慢性难愈皮肤缺损修复的研究, 2016/01-2020/12, 61万元, 在研, 参与

 

发表的论文及专利

[1] Chao Ye, Wang Jianjin, Xu Yiyi, Zheng Ke, Wang Xiaoying,* Ling shengjie,* Kaplan D. L.*. De Novo Synthesis and Assembly of Flexible and Biocompatible Physical Sensing Platforms.Adv. Mater. Technol. 2018,1800141.

[2] Wu, Chaoxi; Wang, Xiaoying; Chu, Bin; Tang, Shunqing; Wang, Yifei. Self-Assembly of Core-Corona β-Glucan into Stiff and Metalizable Nanostructures from 1D to 3D. ACS Nano 2018, 12, 10545−10553.

[3] Zunkai Xu, Ruifang Zhao, Xiuying Huang, Xiaoying Wang, Shunqing Tang. Fabrication and biocompatibility of agarose acetate nanofibrous membrane by electrospinning. Carbohydrate Polymers, 2018, 197: 237-245.

[4] Xiaoying Wang, Yamin Li, Quanshun Li, Caleb Neufeld, Dimitra Pouli, Shuo Sun, Liu Yang, Pu Deng, Ming Wang, Irene Georgakoudi, Shunqing Tang, Qiaobing Xu. Hyaluronic Acid Modification of RNase A and its Intracellular Delivery Using Lipid-like Nanoparticles. J of controlled release, 2017, 263, SI, 39-45.

[5] Wu, Chaoxi; Wang, Xiaoying; Wang, Jianjing; Zhang, Zhen; Wang, Zhiping; Wang, Yifei; Tang, Shunqing. Tile-based self-assembly of a triple-helical polysaccharide into cell wall-like mesoporous nanocapsules, NANOSCALE, 2017, 9(28): 9938-9945.

[6] Liu, Hua; Liu, Wenjun; *Luo, Binghong; Wen, Wei; Liu, Mingxian; Wang, Xiaoying; *Zhou, Changren. Electrospun composite nanofiber membrane of poly(L-lactide) and surface grafted chitin whiskers: Fabrication, mechanical properties and cytocompatibility. Carbohydrate Polymers, 2016, 147: 216-225.

[7] Li, Huihua; Luo, Chuang; *Luo, Binghong; Wen, Wei; Wang, Xiaoying; Ding, Shan; Zhou, Changren. Enhancement of growth and osteogenic differentiation of MC3T3-E1 cells via facile surface functionalization of polylactide membrane with chitooligo-saccharide based on polydopamine adhesive coating. Applied Surface Science, 2016, 360: 858-865.

[8] Hai-Qin Deng, Hui-Heng Lin, Jian-Jin Wang, Jing Lei, Shun-Qing Tang, and XiaoYing Wang*. Design and Synthesis of Linear Biodegradable Elastomers for Soft Tissue Engineering. International Conference on Medicine and Biopharmaceutical (ICMB 2015), Guilin, Guangxi, August 15-16, 2015.

[9] Xu, Wan; Luo, Binghong; Wen, Wei; Xie, Weijing; Wang, Xiaoying; Liu, Mingxian; Zhou, Changren. Surface Modification of Halloysite Nanotubes with L-lactic Acid: An Effective Route to High-Performance Poly(L-lactide) Composites. Journal of Applied Polymer Science, 2015, 132: 41

[10] Jianjin Wang, Haiqing Deng, Huiheng Lin, Zheng Wu, Shunqing Tang, Xiaoying Wang*. Linear Biodegradable Elastomers with Tunable Elastic and Shape-memory Properties for Soft Tissue Engineering. NanoMed, Guangzhou, January 5-7, 2017.

[11] Hai-Qin Deng, Hui-Heng Lin, Jian-Jin Wang, Jing Lei, Shun-Qing Tang, and XiaoYing Wang*. Design and Synthesis of Linear Biodegradable Elastomers for Soft Tissue Engineering. International Conference on Medicine and Biopharmaceutical (ICMB 2015), Guilin, Guangxi, August 15-16, 2015.

[12] 王小莺, 林卉恒, 王剑金, 汤顺清, 武征, 何留民, 罗丙红. 一种形状记忆型高弹性活性纳米纤维支架及其应用. 2016/5/4, 中国，CN201610012439.5. （授权专利）

[13] 王小莺, 汤顺清, 邓海钦, 林卉恒, 武征, 何留民, 罗丙红. 可调控弹性和形状记忆效应的线性可降解聚酯弹性体的制备及应用. 2016/4/20, 中国, CN201610013211.8. （授权专利）

[14] Linmin Zhang, Yueheng Wu, Chaoxi Wu, Xiaoying Wang, Shunqing Tang. An agarose-PEI-HA copolymer as tumor-targeted gene vector with high efficiency and low toxicity. J of controlled release, 2017, 259, e85.

[15] Xiaoying Wang, Sheng Zhong, Lisa A. Gurski, Darrin J. Pochan, Mary C. Farach-Carson and Xinqiao Jia. Amphiphilic block copolyesters bearing pendant cyclic ketal groups as nanocarriers for controlled release of camptothecin. J. Biomater. Sci. Polymer Edn. J. Biomater. Sci. Polymer Edn. 2011, 22, 1275-1298.

[16] Cuiping Guo, Weicai Chen, Shudong Lin, Hao Li, Du Cheng, Xiaoying Wang, Xintao Shuai. Synthesis And Characterization Of Polycation Block Copolymer Poly(L-lysine)-b-Poly[N-(N',N'- Diisopropyl-Aminoethyl)Aspartamide] As Potential pH Responsive Gene Delivery System.  Polymer, 2012, 53, 342-349.

[17] Wang, Xiaoying; Xiao, Longxi; Jia, Xinqiao. Core-stabilized block copolymer micelles for controlled release of cancer therapeutics. PMSE Preprints 2009, 101, 1339-1340.

[18] Wang，Xiaoying; Xiao, Longxi; Liu, Chao; Jia, Xinqiao. Block copolyester micelles as nanocarriers for sustained release of camptothecin. Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) 2009, 50(1), 1472-1473.

[19] Erik Rytting, Michael Bur, Regis Cartier, Thierry Bouyssou, Xiaoying Wang, Michael Krüger, Claus-Michael Lehr, Thomas Kissel. In vitro and in vivo performance of biocompatible negatively charged salbutamol loaded nanoparticles. Journal of Controlled Release, 2010, 141(1), 101-107.

[20] A. Henning, M. Schneider, N. Nafee, L. Muijs, E. Rytting, X. Wang, T. Kissel, D. Grafahrend, D. Klee, C.-M. Lehr. Influence of Particle Size and Material Properties on Mucociliary Clearance from the Airways. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 2010, 23(4):233-241.

[21] MoritzBeck-Broichsitter, Rytting Erik, Tobias Lebhardt, Wang, xiaoying, Kissel Thomas. Preparation of nanoparticles by solvent displacement for drug delivery: A shift in the “ouzo region” upon drugloading. European Journal of Pharmaceutical Sciences. 2010, 41(2), 244-253.

[22] Kissel, Thomas; Wang, xiaoying. Graft polyelectrolyte copolymers as drug delivery systems. PCT Int. Appl. 2009, WO 2009034053A120090319.（授权国际专利）

[23] Wang, xiaoying; Xie, Xiulan; Cai, Cuifang; Rytting, Erik; Steele, Terry; Kissel, Thomas.Biodegradable Branched Polyesters Poly(vinyl sulfonate-covinyl alcohol)-graft Poly(D,L-lactic-coglycolic acid) as a Negatively Charged Polyelectrolyte Platform for Drug Delivery: Synthesis and Characterization. Macromolecules 2008, 41(8), 2791-2799.

[24] Xiaoying Wang, Kairong Liao, Daping Quan and Qing Wu. The Bulk Ring-Opening Polymerization of Lactides Initiated by Ferric alkoxides. Macromolecules, 2005, 38, 4611-4617.

[25] Rytting Erik; Nguyen Juliane; Wang, xiaoying; Kissel Thomas.Biodegradable polymeric nanocarriers for pulmonary drug delivery. Expert Opinion on Drug Delivery 2008, 5(6), 629-39.

 

讲授的课程：

生物材料学，生物医学工程概论，生物材料的表面与界面技术，生物材料的结构与性能