马栋

马栋，暨南大学生物医学工程研究所，研究员，博士生导师

2001至2010年就读于中山大学（本科、博士）；2012年从中山大学博士后流动站出站后入职于暨南大学生命科学技术学院；2013年获评副研究员职称；2017年获博士生导师资格；2018年获评研究员职称。现任暨南大学生物医学工程研究所所长、人工器官及材料教育部工程研究中心副主任等职。

主要研究方向为生物医用高分子。主持国家自然科学基金面上项目等多个科研项目；获广东省科学技术二等奖2项（排名第三、第七）；入选2014年“广东省高等学校优秀青年教师培养计划”、2015年“广州市珠江科技新星”。近五年以通讯作者共发表SCI论文28篇；授权中国发明专利10件，其中转让2件；多次应邀在中国材料大会、抗菌科学与技术论坛等学术会议上做分会邀请报告；获得2021中国生物技术大会优秀专利奖、2022第七届中国创新挑战赛（广东广州）优秀奖等。

一、主持课题：

1、国家自然科学基金面上项目：基于聚轮烷结构的一氧化氮载体的构建及其高效抗菌机制研究；编号：32171369；58万；2022.01-2025.12。

2、国家自然科学基金面上项目：含高代数树枝状聚赖氨酸的超分子水凝胶构建及其高效基因转染机制研究；编号：51573071；64万；2016.01-2019.12。

3、国家自然科学基金青年基金项目：超分子水凝胶用作基因载体的研究；编号：21104099；25万；2012.01-2014.12。

4、广东省高等学校优秀青年教师培养计划：超分子水凝胶基因载体；30万；2015.01-2017.12。

5、广州市珠江科技新星专项：含树枝化基元的氧化还原超分子水凝胶用作基因递送载体的研究；编号：201506010069；30万，2015.04-2018.03。

6、广州市科技计划项目：具有聚集诱导发光效应的载一氧化氮材料的构建及其用于细菌感染的诊疗一体化研究；编号：202102010108；20万，2021.04-2023.03。

7、横向项目：暨南大学—原妙医学联合创新中心；100万，2021.11-2026.12。

8、横向项目：透皮技术与产品开发预研究；40万，2022.03-2022.12。

9、横向项目：新型透明质酸脂质体中试；55万，2022.09-2023.03。

二、5篇代表性论文：

(1)Ziheng Chen, Haitong Zhang, Yuan Lyu, Kai Lv, Hui Xing, Pengfei Shen, Zexiong Guo*, Guowei Li*, Dong Ma*. Octopus‐Inspired Adaptive Molecular Motion for Synergistic Photothermal and Nitric Oxide Antibacterial Therapy in Diabetic Wound Repair. Advanced Functional Materials 2024, 34: 2402591.

(2)Guowei Li, Kai Lv, Qikun Cheng, Hui Xing, Wei Xue, Wu Zhang*, Qianming Lin*, Dong Ma*. Enhanced Bacterial-Infected Wound Healing by Nitric Oxide-Releasing Topological Supramolecular Nanocarriers with Self-Optimized Cooperative Multi-Point Anchoring. Advanced Science 2023, 10: 2206959.

(3)Siming Yu, Guowei Li, Rui Liu, Dong Ma*, Wei Xue*. Dendritic Fe₃O₄@Poly(dopamine)@PAMAM Nanocomposite as Controllable NO-Releasing Material: A Synergistic Photothermal and NO Antibacterial Study. Advanced Functional Materials2018, 28: 1707440.

(4)Siming Yu, Guowei Li, Penghe Zhao, Qikun Cheng, Qianjun He*, Dong Ma*, Wei Xue*. NIR-Laser-Controlled Hydrogen-Releasing PdH Nanohydride for Synergistic Hydrogen-Photothermal Antibacterial and Wound-Healing Therapies. Advanced Functional Materials2019, 28: 1905697.

(5)Hui Xing, Huanqi Peng, Yuhui Yang, Kai Lv, Shihao Zhou, Xiangjun Pan, Jianjin Wang, Yunfeng Hu*, Guowei Li*, Dong Ma*. Nitric oxide synergizes minoxidil delivered by transdermal hyaluronic acid liposomes for multimodal androgenetic-alopecia therapy. Bioactive Materials 2024, 32: 190-205.

三、代表性发明专利（排名第一）：

（1）一种载一氧化氮的羧化壳聚糖-聚乙烯亚胺水凝胶、制备方法及应用，专利号：ZL 201610355430.4，授权时间：2018/07/30。

（2）一种载一氧化氮阳离子聚合物及制备方法及其应用，专利号：ZL 201610356643.9，授权时间：2018/08/06。

（3）载药壳聚糖海藻酸钠双重交联水凝胶及其制法和应用，专利号：ZL 201611054742.8，授权时间：2018/12/20。

（4）一种树枝状分子修饰的荧光量子点及其制备方法和应用，专利号：ZL 201310136530.4，授权时间：2014/10/29。

（5）含树枝状聚赖氨酸基元的星型阳离子聚合物及其制备方法，专利号：ZL 201210005079.8，授权时间：2014/06/25。

四、教学与人才培养：

（1）主持国家级一流课程（虚拟仿真）1门；主持学校教改项目3项

（2）2014年度本科教学校长奖

（3）指导学生获得第七届国际“互联网+”大学生创新创业大赛广东省赛铜奖

（4）指导学生获得第十届“赢在广州”暨粤港澳大湾区大学生创业大赛优胜奖

（5）指导学生获得全国大学生生物医学工程创新设计竞赛一等奖 3 项

（6）指导本科生获得第十三届挑战杯广东省特等奖

Dong Ma, Research Professor and Ph.D. Supervisor, Institute of Biomedical Engineering, Jinan University

1. Education and Career

From 2001 to 2010, he studied at Sun Yat-sen University (Bachelor’s and Ph.D.). In 2012, after completing his postdoctoral fellowship at Sun Yat-sen University, he joined the College of Life Science and Technology at Jinan University. In 2013, he was appointed Associate Researcher. In 2017, he obtained the qualification as a Ph.D. supervisor. In 2018, he was promoted to Researcher. He currently serves as the Director of the Institute of Biomedical Engineering at Jinan University and Deputy Director of the Engineering Research Center for Artificial Organs and Materials, Ministry of Education.

2. Research Focus

His main research direction is biomedical polymers. He has led multiple research projects, including those funded by the National Natural Science Foundation of China (General Program). He received two second-class awards of Guangdong Provincial Scientific and Technological Progress Award (ranked third and seventh). He was selected for the "Outstanding Young Teacher Training Program of Guangdong Higher Education Institutions" in 2014 and the "Guangzhou Pearl River Science and Technology Nova" in 2015. In the past five years, as the corresponding author, he has published 28 SCI papers. He has been granted 10 authorized Chinese invention patents, of which 2 have been transferred. He has been invited to deliver session presentations at several academic conferences, including the China Materials Conference and the Forum on Antimicrobial Science and Technology. He received the Excellent Patent Award at the 2021 China Biotechnology Conference and the Excellence Award at the 7th China Innovation Challenge (Guangzhou, Guangdong) in 2022.

3. Research Projects Led

(1) General Program of the National Natural Science Foundation of China (NSFC): Construction of a Polyrotaxane-Based Nitric Oxide Carrier and Its High-Efficiency Antibacterial Mechanism, 2022.01–2025.12.

(2) General Program of the National Natural Science Foundation of China (NSFC): Construction of a Supramolecular Hydrogel Containing High-Algebra Dendritic Polylysine and Its High-Efficiency Gene, 2016.01–2019.12.

(3) Young Scientists Fund of the National Natural Science Foundation of China (NSFC): Study on Supramolecular Hydrogels as Gene Carriers, 2012.01–2014.12.

(4) Guangdong Province Outstanding Young University Teachers Training Program: Supramolecular Hydrogel-Based Gene Carriers, 2015.01–2017.12.

(5) Guangzhou Pearl River Science and Technology Nova Program: Study on Redox-Responsive Supramolecular Hydrogels Containing Dendritic Motifs as Gene Delivery Vectors, 2015.04–2018.03.

(6) Industry Collaboration Project: Jinan University–Yuanmiao Medical Joint Innovation Center, 2021.11–2026.12.

(7) Industry Collaboration Project: Preliminary Research on Transdermal Technology and Product Development, 2022.03–2022.12.

(8) Industry Collaboration Project: Pilot-Scale Production of a Novel Hyaluronic Acid Liposome, 2022.09–2023.03.

4. Five Representative Publications

(1) Ziheng Chen, Haitong Zhang, Yuan Lyu, Kai Lv, Hui Xing, Pengfei Shen, Zexiong Guo*, Guowei Li*, Dong Ma*. Octopus-Inspired Adaptive Molecular Motion for Synergistic Photothermal and Nitric Oxide Antibacterial Therapy in Diabetic Wound Repair. Advanced Functional Materials 2024, 34: 2402591.

(2) Guowei Li, Kai Lv, Qikun Cheng, Hui Xing, Wei Xue, Wu Zhang*, Qianming Lin*, Dong Ma*. Enhanced Bacterial-Infected Wound Healing by Nitric Oxide-Releasing Topological Supramolecular Nanocarriers with Self-Optimized Cooperative Multi-Point Anchoring. Advanced Science 2023, 10: 2206959.

(3) Siming Yu, Guowei Li, Rui Liu, Dong Ma*, Wei Xue*. Dendritic Fe3O4@Poly(dopamine)@PAMAM Nanocomposite as Controllable NO-Releasing Material: A Synergistic Photothermal and NO Antibacterial Study. Advanced Functional Materials 2018, 28: 1707440.

(4) Siming Yu, Guowei Li, Penghe Zhao, Qikun Cheng, Qianjun He*, Dong Ma*, Wei Xue*. NIR-Laser-Controlled Hydrogen-Releasing PdH Nanohydride for Synergistic Hydrogen-hotothermal Antibacterial and Wound-Healing Therapies. Advanced Functional Materials 2019, 28: 1905697.

(5) Hui Xing, Huanqi Peng, Yuhui Yang, Kai Lv, Shihao Zhou, Xiangjun Pan, Jianjin Wang, Yunfeng Hu*, Guowei Li*, Dong Ma*. Nitric oxide synergizes minoxidil delivered by transdermal hyaluronic acid liposomes for multimodal androgenetic-alopecia therapy. Bioactive Materials 2024, 32: 190-205.

5. Five Representative Invention Patents (First Inventor)

(1) A Spherical PAMAM Polymer Capable of Simultaneously Loading NO and Amphotericin B, and Its Preparation Method and Application; Patent No.: ZL202010410721.5; Granted on: 2023/04/07.

(2) A Colon-Targeted Oral Probiotic Microcapsule, and Its Preparation Method and Application; Patent No.: ZL202110471551.6; Granted on: 2022/10/14.

(3) A Nitric Oxide-Releasing Ointment, and Its Preparation Method and Application; Patent No.: ZL201910793850.4; Granted on: 2021/12/17.

(4) A Polyrotaxane-Structured NO Donor Material, and Its Preparation Method and Application; Patent No.: ZL201910805857.3; Granted on: 2021/07/27.

(5) A β-Galactose-Modified Nitric Oxide Sustained-Release Hydrogel, and Its Preparation Method and Application; Patent No.: ZL201910805857.3; Granted on: 2021/06/11.

6. Teaching and Talent Development

(1) Led a national-level first-class course (virtual simulation) and three university-level teaching reform projects.

(2) Recipient of the 2014 Undergraduate Teaching President’s Award.

(3) Supervised students to win the Bronze Award in the 7th International "Internet+" College Student Innovation and Entrepreneurship Competition (Guangdong Provincial Competition).

(4) Guided students to achieve the Winner’s Award in the 10th "Win in Guangzhou" Guangdong-Hong Kong-Macao Greater Bay Area University Student Entrepreneurship Competition.

(5) Supervised students who won three First Prizes in the National College Student Biomedical Engineering Innovation Design Competition.

(6) Mentored undergraduate students to achieve the Grand Prize in the 13th "Challenge Cup" Guangdong Provincial Competition.